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Understanding MBC > What is CDK4/6 Pathway?

What is CDK4/6 Pathway? 

Cyclin-dependent kinase 4 and 6, or CDK4/6, are protein enzymes that play a key role in signaling pathways inside cells that control normal cell growth. A variety of factors can influence this signaling pathway, leading to faster cell growth and potentially normal cells growing without control and becoming cancerous.

Given the key role of CDK4/6 within this signaling pathway, Fortunately, there are cancer treatments such as CDK4/6 inhibitors, which are designed to target CDK4/6 enzymes to stop or slow the growth of the cancer by turning off the signals that tell cells to grow.

Hear Dr. Cardoso explain the different types of metastatic breast cancer and why this is important for your treatment


  1. CDK4/6 and targeted therapy. Accessed December 19, 2019.